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   » » Wiki: Cushing Ulcer
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Cushing ulcer
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A Cushing ulcer, named after , is a associated with elevated intracranial pressure. It is also called von Rokitansky–Cushing syndrome. Apart from the , ulcers may also develop in the proximal and distal .


Causes
The mechanism of development of Cushing ulcers is thought to be due to direct stimulation of vagal nuclei as a result of increased intracranial pressure. Brain tumors, traumatic head injury, and other intracranial processes including infections, can cause increased intracranial pressure and lead to overstimulation of the vagus nerve. Efferent fibers of the then release onto gastric M3 receptors, causing insertion of hydrogen potassium ATPase vesicles into the apical plasma membrane. The end result is increased secretion of with eventual ulceration of the gastric mucosa.


Diagnosis
As Cushing ulcers have a higher incidence of developing after shock, or trauma, diagnosis should include recent medical history evaluation. Both and can be used to locate the or , though endoscopy is more commonly used as a first-line diagnosis procedure.


Treatment
Most episodes of Cushing ulceration resolve on medical intervention, consisting primarily of rinsing the area with saline and the administration of .


See also


External links
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